Issue: Newsletter 2 | August 1, 2025

Randomised Controlled Trials

Paton NI, Cousins C, Sari IP, Burhan E, Ng NK, Dalay VB, et al. Efficacy and safety of 8-week regimens for the treatment of rifampicin-susceptible pulmonary tuberculosis (TRUNCATE-TB): a prespecified  exploratory analysis of a multi-arm, multi-stage, open-label, randomised  controlled trial. Lancet Infect Dis. 2025 May 22. doi:10.1016/S1473-3099(25)00151-3

Weiner I, Kahan-Hanum M, Buchstab N, Zelcbuch L, Navok S, Sherman I, et al. Phage therapy with nebulized cocktail BX004-A for chronic Pseudomonas aeruginosa infections in cystic fibrosis: a randomized first-in-human trial. Nat Commun. 2025 Jul 1;16:5579. doi: 10.1038/s41467-025-60598-4

Sankar J, Manoharan A, Lodha R, Sharma HP, Kabra SK. Vitamin C Versus Placebo in Pediatric Septic Shock (VITACiPS) - A Randomised Controlled Trial. J Intensive Care Med. 2025 Jul 24. doi:10.1177/08850666251362121

Daikos GL, Cisneros JM, Carmeli Y, Wang M, Leong CL, Pontikis K, et al. Aztreonam-avibactam for the treatment of serious infections caused by metallo-β-lactamase-producing Gram-negative pathogens: a Phase 3 randomized trial (ASSEMBLE). JAC Antimicrob Resist. 2025 Aug;7(4). doi:10.1093/jacamr/dlaf131

Dekkers BGJ, Kerstjens HAM, Breisnes HW, Leeming DJ, Anthony RM, Frijlink HW, et al. Azithromycin as Host-Directed Therapy for Pulmonary Tuberculosis: A Randomized Pilot Trial. J Infect Dis. 2025 May 15;231(5):e891-e900. doi:10.1093/infdis/jiaf069

Lemiale V, Resche-Rigon M, Zerbib Y, Mokart D, De Prost N, Wallet F, et al. Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia (PIC): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med. 2025 Jul 10. doi:10.1016/S2213-2600(25)00125-0

Puttagunta S, Aronin SI, Gupta J, Das AF, Gupta K, Dunne MW. Sulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated Urinary Tract Infection. NEJM Evid. 2025 Jun 24;4(7). doi:10.1056/EVIDoa2400414

• Editorial
  Letourneau AR, Baden LR. Managing Individual and Community Risk - Broad-Spectrum Antimicrobial Use. NEJM Evid. 2025 Jun 24;4(7). doi:10.1056/EVIDe2500070
  

Minja LT, van der Feltz I, Manyama C, Mpagama S, Mhimbira F, Noreña I, et al. Delpazolid in combination with bedaquiline, delamanid, and moxifloxacin for pulmonary tuberculosis (PanACEA-DECODE-01): a prospective, randomised, open-label, phase 2b, dose-finding trial. Lancet Infect Dis. 2025 Jul 8. doi:10.1016/S1473-3099(25)00289-0

Heinrich N, Manyama C, Koele SE, Mpagama S, Mhimbira F, Sebe M, et al. Sutezolid in combination with bedaquiline, delamanid, and moxifloxacin for pulmonary tuberculosis (PanACEA-SUDOCU-01): a prospective, open-label, randomised, phase 2b dose-finding trial. Lancet Infect Dis. 2025 Jul 8. doi:10.1016/S1473-3099(25)00213-0

Nguyen M, Alvarez M, Evezard C, Berthoud V, Leleu D, Pais-De-Barros JP, et al. Endotoxin removal by the OXIRIS filter for cardiogenic shock requiring veno-arterial extra-corporeal life support: the ECMORIX randomized controlled trial. Ann Intensive Care. 2025 Jul 8;15:92. doi:10.1186/s13613-025-01499-z

Naslowski JB, Schieferdecker MEM, Campos ACL. Effects of probiotic supplementation on infectious and gastrointestinal complications of critically ill patients: Randomized, blinded, placebo-controlled clinical trial. Clin Nutr ESPEN. 2025 Aug;68:228-37. doi:10.1016/j.clnesp.2025.05.006

Voiriot G, Argaud L, Cohen Y, Tuffet S, Chauvelot L, Souweine B, et al. Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial. Intensive Care Med. 2025 Jul 15. doi:10.1007/s00134-025-08014-9

Ke L, Li G, Mao W, et al. Early versus delayed catheter drainage for patients with necrotizing pancreatitis and early persistent organ failure (TIMING): a multicenter randomized controlled trial. Intensive Care Med. 2025 Jul 14. doi:10.1007/s00134-025-08020-x

Escrihuela-Vidal F, Ong SWX, Oriol I, Grillo S, Pujol M, Pallarès N, et al. Adjunctive fosfomycin for the treatment of Staphylococcus aureus bacteremia: a pooled post-hoc analysis of individual participant data from two randomized trials. Clin Infect Dis. 2025 Jul 16. doi:10.1093/cid/ciaf387

Targeted Trial Emulation

Huespe IA, Huaier Arriazu EF, Sanchez M, Stanek V, Pollán JA, Bauque S, et al. Mortality of metallo-β-lactamase-producing Enterobacterales bacteremias with combined ceftazidime-avibactam plus aztreonam vs. other active antibiotics: a multicenter target trial emulation. Lancet Reg Health Am. 2025 Sep;49:101175. doi:10.1016/j.lana.2025.101175

Antiobiotic Use

Nandi A, Van Boeckel TP, Klein EY, Denoel P, Cipriano M, Batheja D, et al. Global trends in antibiotic expenditure: analysis of pharmaceutical sales data, 2013 to 2023. J Infect Dis. 2025 Jul 3. doi:10.1093/infdis/jiaf346

Priyadarshi M, Paul SS, Sikdar S, Wig N, Soneja M. Antibiotic-induced Bartter-like syndrome: a systematic review. J Antimicrob Chemother. 2025 May 21;80(7):1784-91. doi:10.1093/jac/dkaf154

Schouwenburg S, Preijers T, Flint RB, Wildschut ED, Koch BCP, de Winter BCM, et al. Prediction of vancomycin area under the curve with trough concentrations only: performance evaluation of pediatric population pharmacokinetic models. J Infect Dis. 2025 Feb 4;231(5):e882-90. doi:10.1093/infdis/jiaf059

Tsai S, Nigo M, Kang D, Baptista RP, Tamma PD, Jacobs E, et al. Cefepime-zidebactam therapy for extensively drug-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae infection as a bridge to liver transplantation. JAC Antimicrob Resist. 2025 Jul 17;7(4):dlaf129. doi:10.1093/jacamr/dlaf129

Huralska M, Pogue JM, Rybak M, Abdul-Mutakabbir JC, Stamper K, Marchaim D, et al. The impact of synergistic therapy between colistin and meropenem on outcomes of patients with pneumonia or bloodstream infection due to carbapenem-resistant Gram-negative pathogens. Clin Infect Dis. 2025 Jul 19. doi:10.1093/cid/ciaf398

Huttner A. Do antibiotic combinations proposed from in vitro studies lead to changes in treatments? REVIVE by GARDP; 2025 Jul 8. Available from: https://revive.gardp.org/do-antibiotic-combinations-proposed-from-in-vitro-studies-lead-to-changes-in-treatments/

Head K, Chong LY, Bhutta MF, Daw J, Veselinović T, Morris PS, et al. Antibiotics versus topical antiseptics for chronic suppurative otitis media. Cochrane Database Syst Rev. 2025 Jun 9;6(6):CD013056. doi:10.1002/14651858.CD013056.pub3

Lau R, Sadeghi H, Ahmadi F, Chalabianloo N, Preyra R, Omrani MA, et al. Trimethoprim/sulfamethoxazole and risk of haemophagocytic lymphohistiocytosis (HLH): a literature review and disproportionality analysis using individual case safety reports from FAERS. J Antimicrob Chemother. 2025 Jul 15. doi:10.1093/jac/dkaf231

Tan Z, Liang W, Zhang N, Liang B, Bai N, Cai Y. Efficacy and safety of earlier switching to an oral antibiotic therapy for the treatment of Gram-positive bloodstream infections: a systematic review and meta-analysis. J Antimicrob Chemother. 2025 Jul 15. doi:10.1093/jac/dkaf209

Giacobbe DR, Vena A, Bassetti M. Role of artificial intelligence in ICU therapeutic decision-making for severe infections. Curr Opin Crit Care. 2025 Jul 7. doi:10.1097/MCC.0000000000001304

Gross BJ, Donahue A, Ford JS, Lu X, Boussina A, Malhotra A, et al. Mortality and antibiotic timing in deep learning-derived surviving sepsis campaign risk groups: a multicenter study. Crit Care. 2025 Jul 14;29:302. doi:10.1186/s13054-025-05493-6

Utley LM, Larsen S, Goldberg T, Barjasteh T. Daptomycin and acute lung injury: recognising drug-induced eosinophilic pneumonia. BMJ Case Rep. 2025 Jul 18;18:e266295. doi:10.1136/bcr-2025-266295

Li X, Zhang C, Li J, Chen T, Xie J, Huang Y, et al. Multicentre open-label randomised controlled trial comparing the efficacy and safety of colistin-based combination therapy with the best available therapy for treating hospital-acquired pneumonia or bloodstream infections caused by carbapenem-resistant Enterobacteriaceae (COUNT-CRE): a study protocol. BMJ Open. 2025;15:e092157. doi:10.1136/bmjopen-2024-092157

Phage Therapy

Hayakawa K, Kiga K, Ojima S, Chihara K, Tamura A, Yamashita W, et al. A feasibility study for personalized phage therapy against drug-resistant bacteria in Japan. J Infect Chemother. 2025 Sep;31(9):102770. doi:10.1016/j.jiac.2025.102770

Bacterial Infections

Linkevicius M, Alm E, Roer L, Svartström O, Dada-Olorunwa M, Räisänen K, et al. Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in Klebsiella pneumoniae: a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024. Euro Surveill. 2025;30(27). doi:10.2807/1560-7917.ES.2025.30.27.2500439

Zhang F, Liu X, Li Z, Li Z, Lei Z, Fan Y, et al. Tracking international and regional dissemination of the KPC/NDM co-producing Klebsiella pneumoniae. Nat Commun. 2025 Jul 1;16:5574. doi:10.1038/s41467-025-60765-7

Quintin J, Le Thuaut A, Plouvier F, Zerbib Y, Sirodot M, Sedillot N, et al. Characteristics and outcomes of ICU patients with sepsis transmitted by cats and dogs: the PETSEPSIS multicentre retrospective observational cohort study. Crit Care. 2025 Jul 22;29:315. doi:10.1186/s13054-025-05558-6

Boutzoukas A, Doi Y. The global epidemiology of carbapenem-resistant Acinetobacter baumannii. JAC Antimicrob Resist. 2025 Aug;7(4). doi:10.1093/jacamr/dlaf134

Castanheira M, Simner PJ, Bradford PA. Extended-spectrum β-lactamases: an update on their characteristics, epidemiology and detection. JAC Antimicrob Resist. 2021 Sep;3(3). doi:10.1093/jacamr/dlab092

Woodhouse EW, Fowler VG Jr, Alsoubani M, Duffy EM, Roach DJ, Grossman TH. Infection risk associated with colonization by multidrug-resistant Gram-negative bacteria: an umbrella review and meta-analysis. Open Forum Infect Dis. 2025 Jul 2;12(7):ofaf365. doi:10.1093/ofid/ofaf365

Lourens R, Singh G, Arendse T, Thwaites G, Rohlwink U. Tuberculous meningitis across the lifespan. J Infect Dis. 2025 Apr 8;231(5):1101-11. doi:10.1093/infdis/jiaf181

Paranos P, Siopi M, Papanikolaou E, Vourli S, Kolia P, Pournaras S, et al. Reversal of phenotypic resistance in multi-drug resistant carbapenemase-producing K. pneumoniae clinical isolates due to in vitro synergistic interactions between bacteriophages and antibiotics at clinically achievable concentrations. J Antimicrob Chemother. 2025 May 31;80(7):1997-2006. doi:10.1093/jac/dkaf163

Gupta K, Wagenlehner F, Wilcox M, Advani SD, Bilsen M, Bonkat G, et al. Urinary tract infection in adults: gaps in current guidelines - opinions from an international multidisciplinary panel and relevance to clinical practice. BMC Proc. 2025 Jul 3;19(Suppl 16):18. doi:10.1186/s12919-025-00333-5

Liu Y, Wang Z, Jian Z, Liu P, Li Y, Qin F, et al. Nosocomial transmission, adaption and clinical outcomes of carbapenem-resistant hypervirulent Klebsiella pneumoniae. BMC Microbiol. 2025 Jul 2;25:376. doi:10.1186/s12866-025-04096-z

Valladares C, Gregory B, Seeburun S, Al Mahrizi AD, Shambhavi S, Kaplan A, et al. Prophylactic inhaled antibiotics for ventilator-associated pneumonia: a systematic review and meta-analysis of incidence and mortality outcomes. Lung. 2025 Jul 5;203:75. doi:10.1007/s00408-025-00827-1

Sakr C, Danjean M, Cizeau F, Ducellier D, Debi MN, Royer G, et al. Unexpected natural cefiderocol resistance in Stenotrophomonas maltophilia associated to the genogroup 4 genetic background. Clin Microbiol Infect. 2025 Jul 6. doi:10.1016/j.cmi.2025.07.001

Cox SR, Moe AH, Gupte AN, Kadam A, Valawalkar S, Gupte N, et al. A point-of-care prediction tool for recurrent tuberculosis. Clin Infect Dis. 2025 Jul 8. doi:10.1093/cid/ciaf353

Li Y, Zhang Y, Song L, Cai C, Chen Y, Yi H, et al. A short, all-oral regimen for pre-extensively drug-resistant tuberculosis: a multicenter open-label single-arm study. Clin Infect Dis. 2025 Jul 8. doi:10.1093/cid/ciaf351

Simar SR, Tran TT, Rydell KB, Atterstrom RL, Sahasrabhojane PV, Dinh AQ, et al. Clinical and genomic characterization of recalcitrant enterococcal bacteremia: a multicenter prospective cohort study (VENOUS). J Infect Dis. 2025 Jul 8. doi:10.1093/infdis/jiaf358

MacLean ELH, Pham YN, Pham CD, Nguyen BC, Garden FL, Hasan T, et al. Long-term outcomes among people with multi-drug resistant tuberculosis in Vietnam: a prospective cohort study. Clin Infect Dis. 2025 Jul 9. doi:10.1093/cid/ciaf363

Buttenschoen J, Kowalewska-Grochowska K, Kleinman D, Cooper R, MacDonald C, Girgis S, et al. First human infection and management of Versteria rafei infection restricted to the liver with phylogenetic analysis in the context of known cases. Lancet Infect Dis. 2025 Jun 19. doi:10.1016/S1473-3099(25)00281-6

Medugu N, Michelow IC, Poole C, Obaro SK. Azithromycin mass drug administration: balancing survival benefits and risks in children. Lancet Infect Dis. 2025 Jul 9. doi:10.1016/S1473-3099(25)00363-9

Flamant A, Demirjian A, Lamagni T, Toubiana J, Smeesters PR, Cohen JF. Invasive group A streptococcal infections: lessons learned from the 2022-23 upsurge. Lancet Infect Dis. 2025 Jul 9. doi:10.1016/S1473-3099(25)00343-3

Jennings MR, Elhaissouni N, Colantuoni E, Prochaska EC, Johnson J, Xiao S, et al. Epidemiology and mortality of invasive Staphylococcus aureus infections in hospitalized infants. JAMA Pediatr. 2025;179(7):747-55. doi:10.1001/jamapediatrics.2025.0429

Matsuo T, Thompson AL, Yuan BJ, Suh GA. The latest approaches to fracture-related infection. Curr Infect Dis Rep. 2025 Jul 4;27:15. doi:10.1007/s11908-025-00864-0

Hinthong W, Phelan J, Hussain A, Mazumder R, Azra, Ul Haq IU, et al. Genomic insights into Klebsiella pneumoniae: virulence, resistance, and transmission in South and Southeast Asia. Int J Med Microbiol. 2025 Jul 18:151666. doi:10.1016/j.ijmm.2025.151666

Sierra R, Roch M, Prados J, Nguyen A, Cherkaoui A, Renzi G, et al. Horizontal transmission of a multidrug-resistant IncM1 plasmid harbouring blaOXA-48 and blaCTX-M-14b among patient microbiotas. J Antimicrob Chemother. 2025 Jul 18. doi:10.1093/jac/dkaf228

Buyukyanbolu E, Argotsinger J, Beck ET, Chamberland RR, Clark AE, Daniels AR, et al. Activity of ampicillin-sulbactam, sulbactam-durlobactam, and comparators against Acinetobacter baumannii-calcoaceticus complex strains isolated from respiratory and bloodstream sources: results from ACNBio study. Antimicrob Agents Chemother. 2025 Jul 17. doi:10.1128/aac.00379-25

Carr MA, Chou SR, Sun J, LaRock DL, LaRock CN. Therapeutic inhibition of metalloproteases by tetracyclines during infection by multidrug-resistant Pseudomonas. J Infect Dis. 2025 Jul 8. doi:10.1093/infdis/jiaf355

Wang B, Giles L, Andraweera P, McMillan M, Beazley R, GradCert SA, et al. Long-term protection against invasive meningococcal B disease and gonococcal infection five years after implementation of funded childhood and adolescent 4CMenB vaccination program in South Australia: an observational cohort and case-control study. Clin Infect Dis. 2025 Jul 10. doi:10.1093/cid/ciaf372

Kubin CJ, Garzia C, Uhlemann AC. Acinetobacter baumannii treatment strategies: a review of therapeutic challenges and considerations. Antimicrob Agents Chemother. 2025 Jul 9. doi:10.1128/aac.01063-24

Vrysis C, Kontogiannis DS, Ntourakis D, Kakoullis SA, Falagas ME. Risk factors for colistin-resistant, extensively drug-resistant (XDR) and pandrug-resistant (PDR) Acinetobacter baumannii infections: a review. Expert Rev Anti Infect Ther. 2025 Jul 9. doi:10.1080/14787210.2025.2532024

Wang Q, Zhou L, Chen X, Yao J, Sun X, Peng K, et al. Global emergence and transmission dynamics of carbapenemase-producing Citrobacter freundii sequence type 22 high-risk international clone: a retrospective, genomic, epidemiological study. Lancet Microbe. 2025 Jul 16. doi:10.1016/j.lanmic.2025.101149

Meyer Sauteur PM. Mycoplasma pneumoniae: re-emergence and beyond. Lancet Microbe. 2025 Jul 16. doi:10.1016/j.lanmic.2025.101191

Imaeda T, Oami T, Yokoyama T, Nakagawa S, Ogura H, Shime N, et al. Epidemiology and outcomes of septic shock in Japan: a nationwide retrospective cohort study from a medical claims database by the Japan Sepsis Alliance (JaSA) study group. Crit Care. 2025 Jul 16;29:309. doi:10.1186/s13054-025-05556-8

Tabah A, De Waele J, Ssi Yan Kai N, Aslan AT, Buetti N, Timsit JF, et al. Source control in bloodstream infections in patients with sepsis, septic shock, or requiring ICU admission: a scoping review with recommendations for standardizing research. Intensive Care Med. 2025 Jul 14. doi:10.1007/s00134-025-08026-5

Martin-Loeches I, Reyes LF, Rodriguez A. Severe community-acquired pneumonia (sCAP): advances in management and future directions. Thorax. 2025. doi:10.1136/thorax-2024-222296

Adrião D, Mojoli F, Gregorio Hernandez R, De Luca D, Bouhemad B, Mongodi S. Ventilator-associated pneumonia: an update on the role of lung ultrasound in adult, pediatric, and neonatal ICU practice. Ther Adv Pulm Crit Care Med. 2025;20. doi:10.1177/29768675251349632

Manzoni P, Kaufman DA, Niklas V, Giuffrè M, Ramelet AS, De Luca D. Expert review of CLABSI prevention in the NICU: supporting the transition of investigational drugs into clinical practice. Eur J Pediatr. 2025 Jul 19;184:492. doi:10.1007/s00431-025-06329-9

Leonard D, Boyd A, Dugon MM. Adding insult to injury: a review of infections following envenomings. Toxicon X. 2025 Sep;27:100230. doi:10.1016/j.toxcx.2025.100230

Tedesco S, Di Grezia M, Tropeano G, Altieri G, Brisinda G. Necrotizing soft tissue infections: a surgical narrative review. Updates Surg. 2025 Aug;77:1239-51. doi:10.1007/s13304-025-02222-0

De la Rosa-Riestra S, Gutiérrez-Gutiérrez B, López-Hernández I, Pérez-Rodríguez MT, Goikoetxea Agirre J, Plata A, et al. External validation of the predictive ability of Charson, SOFA, Pitt, INCREMENT-ESBL and bloodstream infection mortality Risk for 30-day-mortality in bacteraemia using the PROBAC cohort data. Infect Dis. 2025 Jul 9. doi:10.1080/23744235.2025.2527681

Matson AP, Unterhauser K, Rezaul K, Lesmes S, et al. Source-tracking Klebsiella outbreaks in premature infants using a novel amplicon fingerprinting method. Antimicrob Resist Infect Control. 2025 Jul 9;14:83. doi:10.1186/s13756-025-01609-3

Fungal Infections

Smith DJ, Misas E, Gold JAW, Evert N, Dang T, Prot E, et al. Fungal meningitis in U.S. patients who received epidural anesthesia in Matamoros, Mexico. Clin Infect Dis. 2025 Jul 22. doi:10.1093/cid/ciaf399

Thorley EV, Hatch J, Li M, Mashida SN, Castagnola E, Mesini A, et al. Liposomal amphotericin B prophylaxis in paediatrics: a systematic review. J Antimicrob Chemother. 2025 Jun 10;80(7):1792-1802. doi:10.1093/jac/dkaf171

Davidson HC, Yau T, Dunstan I, Houston A, Basarab M, Bicanic T. Early use of the novel antifungal rezafungin: a case series and literature review. J Antimicrob Chemother. 2025 May 14;80(7):1885-92. doi:10.1093/jac/dkaf143

Hyldegaard O, Nekludov M, Arnell P, Nedrebø T, Karlsson Y, Madsen MB, et al. Use of hyperbaric oxygen in patients with necrotizing soft tissue infections: a Scandinavian multicenter, prospective, observational cohort. Infect Dis Ther. 2025 Jul 4. doi:10.1007/s40121-025-01184-5

Trelles M, Murillo J, Fuenmayor-González L, Yu-Liu Y, Alexander-León H, Acebo J, et al. Prevalence of invasive fungal infection in critically ill patients: a systematic review and meta-analysis. BMC Infect Dis. 2025 Jul 5;25:896. doi:10.1186/s12879-025-11264-z

Baddley JW, Wolf J, Ardura MI, Badreldin N, Bahr NC, Bloch K, et al. 2025 clinical practice guideline update by the Infectious Diseases Society of America on histoplasmosis: treatment of asymptomatic Histoplasma pulmonary nodules (histoplasmomas) in adults, children, and pregnant people. Clin Infect Dis. 2025 Jul 8. doi:10.1093/cid/ciaf257

Pappas P, Lentz RJ, Stover KR, Wiederhold NP, Ardura MI, Baddley JW, et al. 2025 clinical practice guideline update by the Infectious Diseases Society of America on histoplasmosis: treatment of mild or moderate acute pulmonary histoplasmosis in adults, children, and pregnant people. Clin Infect Dis. 2025 Jul 10. doi:10.1093/cid/ciaf258

Nguyen MH, Leal SM, Ostrosky-Zeichner L, Spec A, Thompson GR, Patterson TF, et al. COVID-19-associated pulmonary aspergillosis in mechanically ventilated patients at 7 US hospitals: epidemiology and estimated likelihood of invasive pulmonary aspergillosis-results of the prospective MSG-017 study. Open Forum Infect Dis. 2025 Jul 17;12(7):ofaf331. doi:10.1093/ofid/ofaf331

López LF, Arenas S, Jimenez A, Ferreira TBD, Parekh DJ, Bracho Rincon O, et al. Improved consistency of Candida auris colonization screening with an anterior nares and hands composite sample. Clin Infect Dis. 2025 Jul 10. doi:10.1093/cid/ciaf365

Rosa R. Re(de)fining how to screen for Candidozyma auris. Clin Infect Dis. 2025 Jul 10. doi:10.1093/cid/ciaf366

Diagnostics

Bock LJ, Spencer DC, Martin BK, Daniels CN, Dyball X, Hind CK, et al. Rapid impedance-based Antimicrobial Susceptibility Testing (iFAST) of Enterobacterales in urinary tract infections. J Infect. 2025 Aug;91(2). doi:10.1016/j.jinf.2025.106549

Asthana V, Martínez Nieves E, Bugga P, Smith C, Dunn T, Narayanasamy S, et al. Development of a rapid, culture-free, universal microbial identification system using internal transcribed spacer targeting primers. J Infect Dis. 2024 Nov 6;231(5):1155-64. doi:10.1093/infdis/jiae545

Warner NC, Alavian N, Dancel R. Practical application of point-of-care ultrasound for the infectious disease clinician. Clin Infect Dis. 2025 Jul 1. doi:10.1093/cid/ciaf348

Tullayaprayouch K, Phuadraksa T, Luk-In S, Pornsuwan S, Changkhundi P, Wichit S, et al. Development of multiplex recombinase polymerase amplification for the rapid detection of five carbapenemase (blaKPC, blaNDM, blaOXA-48-like, blaIMP, and blaVIM) and ten mcr (mcr-1 to mcr-10) genes in blood cultures. Int J Antimicrob Agents. 2025 Jul 5:107567. doi:10.1016/j.ijantimicag.2025.107567

Karichu JK, Pennington M, Bao X, Lander K, Smith TT, Thornberg A. Evaluating the cost-effectiveness of rapid diagnostic testing for the identification of pathogens and resistance genes in bloodstream infections. medRxiv. 2025 Jun. doi:10.1101/2025.06.12.25329483

Khalil S, Paras ML, Eichenberger E, Sohail MR. The next step: role of metagenomic next generation sequencing for microbial detection in culture-negative cardiovascular infections. Clin Infect Dis. 2025 Jul 4. doi:10.1093/cid/ciaf361

Mateos-Haro M, Garcia-Santa-Vinuela A, Molano-Franco D, Solà I, Gordo-Vidal F, Martín-Delgado MC, et al. Recommendations for the use of biomarkers for the management of adults with sepsis: a scoping review and critical appraisal. BMJ Open. 2024. doi:10.1136/bmjopen-2024-090922

Dessajan J, Thy M, Doman M, Stern J, Gallet A, Fouque G, et al. Assessing FilmArray Pneumonia+ panel dynamics during antibiotic treatment to predict clinical success in ICU patients with ventilated hospital-acquired pneumonia and ventilator-associated pneumonia: a multicenter prospective study. Crit Care. 2025 Jul 12;29:301. doi:10.1186/s13054-025-05503-7

Shalom O, Cohen-Lerner I, Adler A. A comparative study of the VITEK® REVEAL™ versus the VITEK2 system in susceptibility testing of NDM-producing enterobacterales and Acinetobacter baumannii directly from positive blood cultures. Eur J Clin Microbiol Infect Dis. 2025 Jul 18. doi:10.1007/s10096-025-05219-0

Alvarez Mulett S, Molina Garcia S, Abu Saleh O, Wolf MJ, Rodning AA, Wengenack NL, et al. Metagenomic next-generation sequencing of cerebrospinal fluid: first year experience at a tertiary referral hospital. Clin Infect Dis. 2025 Jul 16. doi:10.1093/cid/ciaf390

Su PA, Lai PC, Huang YT. Bayesian network meta-analysis provides comprehensive comparison of blood culture contamination rates. Clin Infect Dis. 2025 Jul 17. doi:10.1093/cid/ciaf394

Patel R. A new resistance combatting strategy. APUA Newsl. 2023;41(1):2-3

Zouitni A, Bos PK, Vogel M, Croughs P, Slobbe L, Claus PE, et al. Impact of sonication fluid cultures on prosthetic joint infection diagnosis and management: a microbiology-driven evaluation using IDSA and EBJIS criteria. Clin Infect Dis. 2025 Jul 18. doi:10.1093/cid/ciaf391

Improving Clinical Trials

Asikanius E, Hofner B, Hampson LV, Wassmer G, Jennison C, Mielke T, et al. Clinical trials with interim analyses: standardizing terminology to increase clarity. Trials. 2025 Jul 14;26:247. Doi:10.1186/s13063-025-08942-3

Gerß JWO, Vonthein R. Introduction to Bayesian statistics. Part 36 of a series on the evaluation of scientific publications. Dtsch Arztebl Int. 2025;122:271-6. doi:10.3238/arztebl.m2025.0035

Zampieri FG, Cahusac PMB, Maia IS, Yehya N, Meyer NJ, Li F, et al. Trial analysis and interpretation in critical care using the evidential (likelihood) approach: rationale and practical considerations. Am J Respir Crit Care Med. 2025. doi:10.1164/rccm.202504-0809TR

Boyles T, Bowen AC, Chomba R, Nel J, Davis JS, Tong SYC. Inclusion of a low- and middle-income country site in the Staphylococcus aureus Network Adaptive Platform (SNAP) trial: experiences from Johannesburg. Clin Microbiol Infect. 2025 Jul 4. doi:10.1016/j.cmi.2025.06.032

Vokinger KN, Serra-Burriel M, Glaus CEG, Welti L, Ross JS, Kesselheim AS. Differences between trial populations and approved label populations of new drugs in the United States and Europe (2012 to 2023): a cross-sectional study. Ann Intern Med. 2025 Jul 8. doi:10.7326/ANNALS-24-03242

Jackson H, Shou Y, Azad NABM, Chua JW, Perez RL, Wang X, et al. A comparison of frequentist and Bayesian approaches to the Personalised Randomised Controlled Trial (PRACTical)-design and analysis considerations. BMC Med Res Methodol. 2025;25:149. doi:10.1186/s12874-025-02537-x

Andrews JR, Charalambous S, Churchyard G, Cobelens F, Fernández-Escobar C, Frick M, et al. The participation of people deprived of liberty in tuberculosis vaccine trials: should they be protected from research, or through research? Lancet Infect Dis. 2025 Jun 27. doi:10.1016/S1473-3099(25)00305-6

Augoustides JG. Scoping reviews-understanding their evolution, methodology, context, and contributions to systematic reviews and meta-analyses. J Cardiothorac Vasc Anesth. 2025 Jun 13. doi:10.1053/j.jvca.2025.06.020

Van Hout D, Mouncey P, Harrison D, Bonten M, Derde L, REMAP-CAP European Regional Investigators. Hurdles for the delivery of multinational randomized clinical trials. JAMA Netw Open. 2025 Jul 2;8(7):e2518503. doi:10.1001/jamanetworkopen.2025.18503

Abbasi AB, Curtis LH, Califf RM. The promise of real-world data for research - what are we missing? N Engl J Med. 2025 Jul 19;393(4):318-21. doi:10.1056/NEJMp2416479

Janiaud P, Ioannidis JPA, Kasenda B, Fretheim A, Goodman SN, Hemkens LG. Single-arm trials can provide randomized real-world evidence: the random invitation single-arm trial design. Ann Intern Med. 2025 Jul 15. doi:10.7326/ANNALS-24-0297

Harris PA, Cheng AC. Participants as partners in decentralized clinical trials. NEJM Evid. 2025 Jul 9;4(7). doi:10.1056/EVIDctw2500188

Guidelines

Infectious Diseases Society of America (IDSA). Complicated Urinary Tract Infections (cUTI): Clinical Guidelines for Treatment and Management. IDSA Practice Guidelines. 2025 Jul 17. Available from: https://www.idsociety.org/practice-guideline/complicated-urinary-tract-infections/

Brown NM, Goodman AL, Horner C, Jenkins A, Brown EM. Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK. JAC Antimicrob Resist. 2021 Mar;3(1). doi:10.1093/jacamr/dlaa114

Jones BE, Ramirez JA, Oren E, Soni NJ, Sullivan LR, Restrepo MI, et al. Diagnosis and management of community-acquired pneumonia. An official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med. 2025 Jul 17. doi:10.1164/rccm.202507-1692ST

General Interest

Mohammed S, Herrera ER, Kioka M. Neurotoxic effects of scorpion envenomation, a video of nystagmus, dysmetria, and tongue fasciculations: a case report. J Med Case Rep. 2025 Jul 23;19:362. doi:10.1186/s13256-025-05416-7

Laurens MB. Controlled human infection studies accelerate vaccine development. J Infect Dis. 2025 May 15;231(5):1112-6. doi:10.1093/infdis/jiaf053

Forero-Delgadillo AJ, Morales-Olivera JA, Celis-Guzmán JF, Zapata-Díaz OE, González-Varona GA, Acevedo-Bedoya CA, et al. Colombian consensus on the care of critically ill patients with suspected or confirmed severe yellow fever. Lancet Reg Health Am. 2025 Jun 11. doi:10.1016/j.lana.2025.101144

Le Marechal M, Dumez P, Martinez-Almoyna N, Azouvi P, Broucker TDE, Dubee V, et al. Detection, evaluation and management of the sequelae of infectious encephalitis in adults. Infect Dis Now. 2025 Jun 26. doi:10.1016/j.idnow.2025.105110

Arias CA, van Duin D. What is antimicrobial resistance? JAMA. 2025 Jul 17. doi:10.1001/jama.2025.10052

Kahlmann V, Janssen Bonás M, Moor CC, Grutters JC, Mostard RLM, van Rijswijk HNAJ, et al. First-line treatment of pulmonary sarcoidosis with prednisone or methotrexate. N Engl J Med. 2025 May 18;393(3):231-42. doi:10.1056/NEJMoa2501443

Tangchitthavorngul S, Lumlertgul N, Peerapornratana S, et al. Epidemiology and long-term outcomes of critically ill patients with severe AKI in India and Southeast Asia. Intensive Care Med. 2025 Jul;51:1306-19. doi:10.1007/s00134-025-08008-7

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